REDUCTION OF CYCLOSPORINE DOSAGE WITH KETOCONAZOLE IN A PATIENT WITH BIRDSHOT RETINOCHOROIDOPATHY

PURPOSE: To report the successful reduction of cyclosporine dosage wit h adjunctive ketoconazole in a patient with birdshot retinochoroidopat hy METHOD: Case report. RESULTS: A 55-year-old woman treated with cycl osporine for birdshot retinochoroidopathy had ketoconazole (200 mg/day ) added to her medical regimen. Her cyclosporine dosage was reduced to 40 mg per day from 200 mg per day, an 80% reduction. No toxic effect was observed during 12 months of follow up nor was there progression o f the birdshot retinochoroidopathy. CONCLUSIONS: Cyclosporine dosage m ay be reduced considerably in patients with uveitis who use adjunctive ketoconazole. The regimen appears to be safe and efficacious.