IMMUNOCHEMICAL EVIDENCE FOR INCREASED FORMATION OF ADVANCED GLYCATIONEND-PRODUCTS AND INHIBITION BY AMINOGUANIDINE IN DIABETIC RAT LENSES

Authors
MATSUMOTO K IKEDA K HORIUCHI S ZHAO H ABRAHAM EC
Citation
K. Matsumoto et al., IMMUNOCHEMICAL EVIDENCE FOR INCREASED FORMATION OF ADVANCED GLYCATIONEND-PRODUCTS AND INHIBITION BY AMINOGUANIDINE IN DIABETIC RAT LENSES, Biochemical and biophysical research communications, 241(2), 1997, pp. 352-354
Citations number
14
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
241
Issue
2
Year of publication
1997
Pages
352 - 354
Database
ISI
SICI code
0006-291X(1997)241:2<352:IEFIFO>2.0.ZU;2-3
Abstract
Water-soluble and urea-soluble protein fractions from control and stre ptozotocin-diabetic rats were analyzed for AGE's with a CML-specific m onoclonal anti-AGE antibody and a polyclonal anti-AGE antibody. AGEs, CML in particular, were significantly increased in the diabetic rats w hereas aminoguandine treatment resulted in significant decrease in AGE s. The data also confirm that CML, a glycoxidation product, is a major epitope of AGE structures in lenses. (C) 1997 Academic Press.