Adenocarcinoma of the stomach distal to the cardia remains one of the
most common cancers in the world. The interest in the aetiology of thi
s disease has been rekindled because of recent epidemiological and mol
ecular studies linking this cancer to H, pylori and certain dietary fa
ctors. The authors provide an updated review of the aetiology of gastr
ic cancer. This review seeks to summarize the disease, to propose path
ways of carcinogenesis and to suggest ways in which the ''traditional'
' risk factors may be interpreted on the basis of evolving knowledge.
(C) 1997 Elsevier Science Ltd.