SYNTHESIS OF DIHALOPHENYLACETIC ACIDS USING AROMATIC NUCLEOPHILIC-SUBSTITUTION STRATEGY

Authors
KOWALCZYK BA
Citation
Ba. Kowalczyk, SYNTHESIS OF DIHALOPHENYLACETIC ACIDS USING AROMATIC NUCLEOPHILIC-SUBSTITUTION STRATEGY, Synthesis, (12), 1997, pp. 1411-1414
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
12
Year of publication
1997
Pages
1411 - 1414
Database
ISI
SICI code
0039-7881(1997):12<1411:SODAUA>2.0.ZU;2-X
Abstract
A simple synthetic strategy to dihalophenylacetic acids and specifical ly 3,5-difluorophenylacetic acid an important pharmaceutical intermedi ate was developed. The aromatic nucleophilic substitution of dihaloflu orobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalo phenylcyanoacetates. The basic decarboxylation of the ethyl dihalophen ylcyanoacetates produced targeted dihalophenylacetic acids.