STRUCTURAL-PROPERTIES OF HEPATOCYTE PLASM A-MEMBRANES UNDER EXPOSURE TO CISPLATIN, ADRIABLASTIN AND EMBICHINE

Effects of cisplatin, adriablastin, both drugs applied together, and e mbichine upon structural properties of hepatocyte cell membranes have been studied using fluorescent techniques. All drugs were found to ind uce directed changes in lipid-protein relationships: decrease of the l evel of protein immersion into lipid bilayer. However, other parameter s of cell membrane conformation were differently affected by the drugs under study. Exposure to cisplatin and embichine has no effect on phy sicochemical properties of internal regions of membranes, while adriab lastin and adriablastin with cisplatin induce an increase in microvisc osity of hydrophobic regions of lipid matrix. Cisplatin does not effec t structural properties of cell membrane surface layer, while adriabla stin, applied separately or with cisplatin, induces an increase in flu idity of surface layers of lipids, and embichine produces similar effe cts in surface regions of membrane proteins.