SYNTHESIS OF CERTAIN 1,3,4-OXADIAZOLE DERIVATIVES AS POTENTIAL ANTICONVULSANTS

Compound (2) was used as starting material for the synthesis of the hy drazones (3a-f). Cyclization of (3a-f) by acetic anhydride resulted in the formation of 4-acetyl-5-substituted-1,3,4- oxadiazole derivatives (4a-f). the hydrazide (2) was reacted with benzoic acid in presence o f phosphorus oxychloride and/or carbon disulphide in ethanolic potassi um hydroxide to furnish (5) and (6) respectively, interaction of (2) w ith phenyl isothiocyanate in dioxan gave the thiosemicarbazide derivat ive (7) which was converted into oxadiazole derivative (8). Compound ( 8) was also obtained via reaction of (2) with phenyl isothiocyanate in presence of D.C.C.. Structure of the newly synthesized compounds were confirmed by IR, H-1 NMR, MS and elemental analysis. Compound (4c) an d (6) exhibited good anticonvulsant effects against pentylenetetrazole -induced convulsion in the mice.