SYNTHETIC ROUTES TO THIAZOLO[2,3-B]PYRIMIDIN-7-ONES VIA 2-ALLYLTHIOURACILS

Authors
HEYDAR KT AGHAPOOR K NOOSHABADI MA HERAVI MM
Citation
Kt. Heydar et al., SYNTHETIC ROUTES TO THIAZOLO[2,3-B]PYRIMIDIN-7-ONES VIA 2-ALLYLTHIOURACILS, Indian Journal of Heterocyclic Chemistry, 7(2), 1997, pp. 159-160
Citations number
8
Journal title
Indian Journal of Heterocyclic Chemistry → ACNP
ISSN journal
09711627
Volume
7
Issue
2
Year of publication
1997
Pages
159 - 160
Database
ISI
SICI code
0971-1627(1997)7:2<159:SRTTV2>2.0.ZU;2-M
Abstract
2-Thiouracil: (1, R=Me, R-2=H or Bu) was condensed with allyl bromide to afford the corresponding 2-allylthio derivative (2, R-1=Me, R-2=H o r Bu). The latter was treated with excess of bromine to afford 3-bromo methyl 6,7-disubstituted-2,3-dihydro thiazolo [2,3-b] 5-one (3, R-1=Me , R-2=H, or Bu, R-3=Br) which was reacted with nucleophiles such as mo rpholine and diethylamine to give (3, R-1=Me, R-2=H), R-3=morpholino a nd diethylamino respectively.