Technical progress made in neuroradiology, and focal external and inte
rnal radiation therapy, have allowed the development of a series of lo
cal therapeutic modalities both in primary and in metastatic brain tum
ours. Eligibility criteria and results obtained with these new techniq
ues are compared. Experimental studies with implications for radiation
therapy, particularly boron neutron capture therapy, and for chemothe
rapy are reviewed. The possible use of chemotherapy as first-line trea
tment in non-Hodgkins lymphomas of central nervous system is stressed.
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