EPIDEMIOLOGY OF INFECTION - PNEUMOCOCCI CAUSING INVASIVE DISEASE IN BRITAIN 1982-1990

A total of 5348 isolates of Streptococcus pneumoniae was serotyped and screened for insusceptibility to tetracycline, penicillin, erythromyc in and chloramphenicol. Of these, 4238 (79%) were isolated from patien ts who had pneumonia or meningitis or were bacteraemic. Altogether, 39 48 (74%) of the isolates belonged to one or other of the serotypes 1, 3, 4, 6, 8, 9, 14, 19 or 23 with serotypes 6, 14, 18, 19 and 23 being frequent causes of invasive disease in young children. Many isolates o f type 1 were isolated from pneumonia and few from meningitis. Some 76 8 (14%) isolates were insusceptible to one or more antibiotic and 591 of these belonged to serotypes 6, 9, 14, 19 or 23. Representatives of type 14 resistant to erythromycin were prominent from 1986 onwards. Th ere was an increase in the number of multi-resistant pneumococci from 1985. Among these were isolates of type 23 insusceptible to penicillin , chloramphenicol and tetracycline and cultures of type 6 resistant ad ditionally to erythromycin.