INFLUENCE OF CADMIUM ON LIPID-PEROXIDATION AND ANTIOXIDANT ENZYMES INISOLATED RAT HEPATOCYTES

Authors
SARKAR S YADAV P BHATNAGAR D
Citation
S. Sarkar et al., INFLUENCE OF CADMIUM ON LIPID-PEROXIDATION AND ANTIOXIDANT ENZYMES INISOLATED RAT HEPATOCYTES, Fresenius environmental bulletin, 7(1-2), 1998, pp. 28-33
Citations number
24
Categorie Soggetti
Environmental Sciences
Journal title
Fresenius environmental bulletin → ACNP
ISSN journal
10184619
Volume
7
Issue
1-2
Year of publication
1998
Pages
28 - 33
Database
ISI
SICI code
1018-4619(1998)7:1-2<28:IOCOLA>2.0.ZU;2-9
Abstract
Cadmium (Cd) influences lipid peroxidation (LPO) by enhancing peroxida tion of membrane lipids and by disturbing the antioxidant system of ce lls. In isolated rat hepatocytes, LPO was observed in cells incubated with Cd (50-250 mu M) for various time periods up to 90 min. The antio xidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) w ere inhibited along with depletion of glutathione (GSH) in hepatocytes treated with Cd. The results show that Cd influences LPO in rat hepat ocytes due to decrease in antioxidant status.