METAL-COMPLEXES OF N(4)-SUBSTITUTED ANALOGS OF THE ANTIVIRAL DRUG METHISAZONE (1-METHYLISATIN THIOSEMICARBAZONE)

1-Methylisatin N(4)-methyl- and N(4)-dimethylthiosemicarbazone, HMIs4M and HMIs4DM, respectively, and their cobalt(II), nickel(II) and coppe r(II) complexes have been prepared and characterized, by elemental ana lyses, molar conductivities, magnetic susceptibilities and by spectral methods: i.r., u.v.-vis.-n.i.r., n.m.r. and e.s.r. The two thiosemica rbazones, upon loss of the N(2)H, coordinate as monoanions via the azo methine nitrogen and thiolato sulfur atoms, as well as the isatin oxyg en {i.e. except for [Cu(MIs4M)(2)] and [Cu(MIs4DM)(2)]} to give comple xes of the general formula [M(MIs)(2)] and [M(MIs)Cl] where M = Co-II, Ni-II and Cu-II and MIs = both HMIs4M and HMIs4DM. The preparation wi th HMIs4DM and nickel(II) chloride formed [Ni(MIs4DM)(2)] rather than [Ni(MIs4DM)Cl]. Copper(II) bromide yielded complexes with low magnetic susceptibilities, which are considered to be binuclear {i.e. [Cu(MIs4 M)Br](2) and [Cu(MIs4DM)Br](2)}.