Surgical-site infections, the third most common class of nosocomial in
fections, cause substantial morbidity and mortality and increase hospi
tal costs. Surveillance programs can lead to reductions in surgical-si
te infection rates of 35% to 50%. Herein, we will discuss the practica
l aspects of implementing a hospital-based surveillance program for su
rgical-site infections. We will review surveillance methods, patient p
opulations that should be screened, and interventions that could reduc
e infection rates.