Gl. Bryant et al., HISTOLOGIC-STUDY OF ORAL-MUCOSA WOUND-HEALING - A COMPARISON OF A 6.0TO 6.8-MU-M PULSED-LASER AND A CARBON-DIOXIDE LASER, The Laryngoscope, 108(1), 1998, pp. 13-17
Incisional wound healing in the canine oral mucosa was histologically
monitored at 3, 7, and 14 days after incision, Healing was compared fr
om a scalpel, a carbon dioxide (CO2) laser at 10.6 mu m, and the Vande
rbilt free-electron laser tuned to 6.0, 6.45, and 6.8 mu m. A signific
ant delay in wound healing was observed when incisions were made with
the CO2 laser, probably attributable to the excess thermal damage caus
ed by the continuous-wave laser beam, When using the short pulsed, fre
e-electron laser, a much smaller delay comparable to the scalpel wound
healing was observed, This smaller delay tended to decrease with incr
easing tissue absorption, The results emphasize the greater importance
of laser pulse duration rather than wavelength in relation to the sub
sequent wound healing.