RECRUITMENT, ACTIVATION AND PROLIFERATION OF CD8(-CELLS IN AN IMMUNOPRIVILEGED SITE() MEMORY T)

Citation
Pg. Stevenson et al., RECRUITMENT, ACTIVATION AND PROLIFERATION OF CD8(-CELLS IN AN IMMUNOPRIVILEGED SITE() MEMORY T), European Journal of Immunology, 27(12), 1997, pp. 3259-3268
Citations number
33
ISSN journal
00142980
Volume
27
Issue
12
Year of publication
1997
Pages
3259 - 3268
Database
ISI
SICI code
0014-2980(1997)27:12<3259:RAAPOC>2.0.ZU;2-T
Abstract
The capacity of a memory cytotoxic T lymphocyte (CTL) population to pr otect against viral infections is well established, but the processes underlying this protection are less well understood. We have used hete rotypic intranasal immunization with influenza A/X31 (H3N2) to protect against a subsequent infection with the neurovirulent influenza A/WSN (H1N1) in either the cerebrospinal fluid or the immunoprivileged brai n parenchyma. Viral clearance from both sites was associated with a lo cal infiltration and proliferation of A/WSN-specific CD8(+) T cells. I nfection in the cerebrospinal fluid elicited a proliferative response in the draining lymph nodes, an anti-H1N1 serum antibody response and an increase in the extracerebral A/WSN-specific CTL precursor frequenc y. In contrast, infection in the brain parenchyma elicited no lymph no de proliferative response or serum antibody response and caused a tran sient decrease in the extracerebral CTL precursor frequency. Thus the memory CTL population protected against an intracerebral viral infecti on independent of any immune response occurring in systemic lymphoid t issue.