SHORT-TERM GNRH-ANALOG ADMINISTRATION IN PATIENTS WITH PCOS AND ITS IMPACT ON HEMODYNAMICS AND HORMONAL PROFILE

Purpose: The ovarian response to 14 days of GnRH-analogue (GnRHa) appl ication in patients with polycystic ovary syndrome (PCOS) was evaluate d by measuring hemodynamic parameters and hormonal profile. Methods: T wenty patients with PCOS represented the study group, and 22 patients with normal menstrual cycle (NMC) the reference group. The resistance index (RI) of uteroovarian arterial blood flow and serum level of LH a nd androstendione were measured on days 4, 13, and 22 of the cycle and after 14 days of GnRHa administration. Results: On day 22 of the cycl e the RI in the uterine artery was 0.86 in the PCOS and 0.82 in the NM C group. Throughout the cycle the ovarian arterial blood flow in both oval-ies in the PCOS group was similar to that in inactive ovaries in the NMC group. After the 14-day GnRHa administration the RI of uteroov arian blood flow and the serum level of androstenedione remained uncha nged in, the PCOS group. Conclusions: RI in the uteroovarian blood flo w and serum androstendione level in the PCOS group are not affected by 14-day GnRHa administration.