ANTIMALARIAL EFFECT IN-VITRO AND LACK OF MODULATING EFFECT OF DESIPRAMINE AND IMIPRAMINE

Authors
MENEZES CMS KIRCHGATTER K DISANTI SMF SAVALLI C MONTEIRO FG PAULA GA FERREIRA EI
Citation
Cms. Menezes et al., ANTIMALARIAL EFFECT IN-VITRO AND LACK OF MODULATING EFFECT OF DESIPRAMINE AND IMIPRAMINE, Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(6), 1997, pp. 697-700
Citations number
33
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
91
Issue
6
Year of publication
1997
Pages
697 - 700
Database
ISI
SICI code
0035-9203(1997)91:6<697:AEIALO>2.0.ZU;2-N
Abstract
Based on previous studies in vitro of the modulating effect of desipra mine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian st rains of the parasite was investigated. Both drugs in therapeutic dose s showed an unexpected antimalarial effect in vitro in duplicate tests (IC50=44.26 and 46.53 mu g/L for desipramine, and 83.93 and 41.26 mu g/L for imipramine), but no reversal of resistance when added to cultu res together with chloroquine.