Cms. Menezes et al., ANTIMALARIAL EFFECT IN-VITRO AND LACK OF MODULATING EFFECT OF DESIPRAMINE AND IMIPRAMINE, Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(6), 1997, pp. 697-700
Citations number
33
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Based on previous studies in vitro of the modulating effect of desipra
mine on chloroquine-resistance of Plasmodium falciparum, the effect of
desipramine and imipramine on freshly isolated resistant Brazilian st
rains of the parasite was investigated. Both drugs in therapeutic dose
s showed an unexpected antimalarial effect in vitro in duplicate tests
(IC50=44.26 and 46.53 mu g/L for desipramine, and 83.93 and 41.26 mu
g/L for imipramine), but no reversal of resistance when added to cultu
res together with chloroquine.