SYNTHESIS OF DIMERIC ESTRADIOL ENZYME MODEL CONTAINING IMIDAZOLYL ANDSTUDY ON ITS CATALYTIC EFFICIENCY IN HYDROLYSIS OF CARBOXYLATES AND PHOSPHATES

Authors
YAN JM XIE RG ZHAO HM WU DX XIA PF
Citation
Jm. Yan et al., SYNTHESIS OF DIMERIC ESTRADIOL ENZYME MODEL CONTAINING IMIDAZOLYL ANDSTUDY ON ITS CATALYTIC EFFICIENCY IN HYDROLYSIS OF CARBOXYLATES AND PHOSPHATES, Chinese journal of chemistry, 15(5), 1997, pp. 438-442
Citations number
8
Journal title
Chinese journal of chemistry → ACNP
ISSN journal
1001604X
Volume
15
Issue
5
Year of publication
1997
Pages
438 - 442
Database
ISI
SICI code
1001-604X(1997)15:5<438:SODEEM>2.0.ZU;2-4
Abstract
Dimeric estradiol enzyme model. (2) was synthesized by etherification of 2,4-bis(N-imidazolylmethyl)-17 beta-estradiol (I) with 1,3-dibromop ropane in the presence of anhydrous K2CO3. Hydrolysis of carboxylates and phosphates catalyzed by the model showed Michaelis-Menten kinetic behavior. Hydrophobic interaction between the model and ester accelera tes the hydrolysis markedly, rate enhancement of up to 65 and 285 fold , relative to imidazole, is observed.