SYNTHESIS OF THE C-8-C-15 SEGMENT OF (-DISCODERMOLIDE())

Authors
MIYAZAWA M OONUMA S MARUYAMA K MIYASHITA M
Citation
M. Miyazawa et al., SYNTHESIS OF THE C-8-C-15 SEGMENT OF (-DISCODERMOLIDE()), Chemistry Letters, (12), 1997, pp. 1193-1194
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
12
Year of publication
1997
Pages
1193 - 1194
Database
ISI
SICI code
0366-7022(1997):12<1193:SOTCSO>2.0.ZU;2-7
Abstract
Succeeding to the preceding paper, stereoselective synthesis of the C- 8-C-15 segment of (+)-discodermolide (1), the marine natural product h aving the potent immunosuppressive activity, is described in which the contiguous asymmetric centers at C-11 and C-12 positions were stereos pecifically constructed via the methylation of an epoxy alcohol with l ithium dimethylcuprate.