STRUCTURES OF STAUROSPORINE BOUND TO CDK2 AND CAPK - NEW TOOLS FOR STRUCTURE-BASED DESIGN OF PROTEIN-KINASE INHIBITORS

Authors
TOLEDO LM LYDON NB
Citation
Lm. Toledo et Nb. Lydon, STRUCTURES OF STAUROSPORINE BOUND TO CDK2 AND CAPK - NEW TOOLS FOR STRUCTURE-BASED DESIGN OF PROTEIN-KINASE INHIBITORS, Structure, 5(12), 1997, pp. 1551-1556
Citations number
31
Journal title
Structure → ACNP
ISSN journal
09692126
Volume
5
Issue
12
Year of publication
1997
Pages
1551 - 1556
Database
ISI
SICI code
0969-2126(1997)5:12<1551:SOSBTC>2.0.ZU;2-T
Abstract
Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The re cently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.