INSULIN SELECTIVELY DOWN-REGULATES ALPHA(2)-ADRENOCEPTORS IN THE ARCUATE AND DORSOMEDIAL NUCLEUS

Authors
LEVIN BE ISRAEL P LATTEMANN DPF
Citation
Be. Levin et al., INSULIN SELECTIVELY DOWN-REGULATES ALPHA(2)-ADRENOCEPTORS IN THE ARCUATE AND DORSOMEDIAL NUCLEUS, Brain research bulletin, 45(2), 1998, pp. 179-181
Citations number
30
Categorie Soggetti
Neurosciences
Journal title
Brain research bulletin → ACNP
ISSN journal
03619230
Volume
45
Issue
2
Year of publication
1998
Pages
179 - 181
Database
ISI
SICI code
0361-9230(1998)45:2<179:ISDAIT>2.0.ZU;2-I
Abstract
Intracerebroventricular infusion of insulin (2 mU/day) produced select ive downregulation of H-3-paraminoclonidine binding to alpha(2)-adreno ceptors in the hypothalamic arcuate (14%) and dorsomedial (19%) nuclei out of 16 forebrain areas in Wistar rats, Binding of H-3-prazosin to alpha(1)-adrenoceptors was unaffected. This is in keeping with the kno wn effect of insulin on catecholamine and neuropeptide Y metabolism in these brain regions that play an important role in energy homeostasis . (C) 1998 Elsevier Science Inc.