Be. Levin et al., INSULIN SELECTIVELY DOWN-REGULATES ALPHA(2)-ADRENOCEPTORS IN THE ARCUATE AND DORSOMEDIAL NUCLEUS, Brain research bulletin, 45(2), 1998, pp. 179-181
Intracerebroventricular infusion of insulin (2 mU/day) produced select
ive downregulation of H-3-paraminoclonidine binding to alpha(2)-adreno
ceptors in the hypothalamic arcuate (14%) and dorsomedial (19%) nuclei
out of 16 forebrain areas in Wistar rats, Binding of H-3-prazosin to
alpha(1)-adrenoceptors was unaffected. This is in keeping with the kno
wn effect of insulin on catecholamine and neuropeptide Y metabolism in
these brain regions that play an important role in energy homeostasis
. (C) 1998 Elsevier Science Inc.