SYNTHESIS, STRUCTURE, AND ANTIMETASTATIC ACTIVITY OF THE TRANS-[PT(NC5H4C(O)NHC2H4ONO2)(2)CL-2] COMPLEX

Authors
EREMENKO IL GOLUBNICHAYA MA NEFEDOV SE SIDOROV AA NESTERENKO DA KONOVALOVA NP VOLKOVA LM EREMENKO LT
Citation
Il. Eremenko et al., SYNTHESIS, STRUCTURE, AND ANTIMETASTATIC ACTIVITY OF THE TRANS-[PT(NC5H4C(O)NHC2H4ONO2)(2)CL-2] COMPLEX, Russian chemical bulletin, 46(9), 1997, pp. 1595-1598
Citations number
15
Journal title
Russian chemical bulletin → ACNP
ISSN journal
10665285
Volume
46
Issue
9
Year of publication
1997
Pages
1595 - 1598
Database
ISI
SICI code
1066-5285(1997)46:9<1595:SSAAAO>2.0.ZU;2-3
Abstract
The trans-[Pt(NC5H4C(O)NHC2H4ONO2)(2)CL2] complex (2) was prepared by the reaction of nicorandyl (N-nitroethoxynicotinamide), which is widel y used in cardiology, with K2PtCl4 in water. The structure of 2 was es tablished by X-ray structural analysis. it was found that complex 2 ex hibits high antitumor activity, in particular, antimetastatic activity , unlike the analogous Cu-II complex with bromine atoms.