DETOMIDINE-BUTORPHANOL-PROPOFOL FOR CAROTID-ARTERY TRANSLOCATION AND CASTRATION OR OVARIECTOMY IN GOATS

Objective-To determine the safety and efficacy of propofol, after deto midine-butorphanol premedication, for induction and anesthetic mainten ance for carotid artery translocation and castration or ovariectomy in goats. Study Design-Case series. Animals-Nine 4-month-old Spanish goa ts (17.1 +/- 2.6 kg) were used to evaluate propofol anesthesia for car otid artery translocation and castration or ovariectomy. Methods-Goats were premedicated with detomidine (10 mu g/kg intramuscularly [IM]) a nd butorphanol (0.1 mg/kg IM) and induced with an initial bolus of pro pofol (3 to 4 mg/kg intravenously [IV]). If necessary for intubation, additional propofol was given in 5-mg (IV) increments. Propofol infusi on (0.3 mg/kg/min IV) was used to maintain anesthesia, and oxygen was insufflated (5 L/min). The infusion rate was adjusted to maintain an a cceptable anesthetic plane as determined by movement, muscle relaxatio n, ocular signs, response to surgery, and cardiopulmonary responses. S ystolic (SAP), mean (MAP) and diastolic (DAP) arterial pressures, hear t rate (HR), EGG, respiratory rate (RR), SpO(2), and rectal temperatur e (T) were recorded every 5 minutes postinduction; arterial blood gas samples were collected every 15 minutes. Normally distributed data are represented as mean +/- SD; other data are medians (range). Results-P ropofol (4.3 +/- 0.9 mg/kg TV) produced smooth, rapid (15.2 +/- 6 sec) sternal recumbency. Propofol infusion (0.52 +/- 0.11 mg/kg/min TV) ma intained anesthesia. Mean anesthesia time was 83 +/- 15 minutes. Muscl e relaxation was good; eye signs indicated surgical anesthesia; two go ats moved before surgery began; one goat moved twice during laparotomy . Means are reported over the course of the data collection period. Me ans during the anesthesia for pH, (arterial PH), PaCO2 PaO2, HCO3-, an d BE (base excess) ranged from 7.233 +/- 0.067 to 7.319 +/- 0.026, 54. 1 +/- 4.6 to 65.3 +/- 12.0 mm Hg, 133.1 +/- 45.4 to 183.8 +/- 75.1 mm Hg, 26.9 +/- 2.6 to 28.2 +/- 2.1 mEq/L, and -0.8 +/- 2.9 to 1.4 +/- 2. 2 mEq/L. Means over time for MAP were 53 +/- 12 to 85 +/- 21 mm Hg. Me an HR varied over time from 81 +/- 6 to 91 +/- 11 beats/minute; mean R R, from 9 +/- 8 to 15 +/- 5 breaths/minute; SpO2, from 97 +/- 3% to 98 +/- 3%; mean T, from 36.0 +/- 0.6 degrees C to 39.1 +/- 0.7 degrees C . Over time, SpO2 and SaO2 did not change significantly; HR, RR, T, an d PaCO2 decreased significantly; SAP, DAP, MAP, pH(a), PaO2, and BE in creased significantly. HCO3- concentrations increased significantly, p eaking at 45 minutes. Recoveries were smooth and rapid; the time from the end of propofol infusion to extubation was 7.3 +/- 3 minutes, to s ternal was 9.2 +/- 5 minutes, and to standing was 17.7 +/- 4 minutes. Median number of attempts to stand was two (range of one to four). Pos toperative pain was mild to moderate. Conclusions-Detomidine-butorphan ol-propofol provided good anesthesia for carotid artery translocation and neutering in goats. Clinical Relevance-Detomidine-butorphanol-prop ofol anesthesia with oxygen insufflation may be safely used for surgic al intervention in healthy goats. (C) Copyright 1998 by The American C ollege of Veterinary Surgeons.