SELECTIVE CYTOTOXICITY OF GINKGETIN FROM SELAGINELLA-MOELLENDORFFII

Authors
SUN CM SYU MJ HUANG YT CHEN CC OU JC
Citation
Cm. Sun et al., SELECTIVE CYTOTOXICITY OF GINKGETIN FROM SELAGINELLA-MOELLENDORFFII, Journal of natural products, 60(4), 1997, pp. 382-384
Citations number
28
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
4
Year of publication
1997
Pages
382 - 384
Database
ISI
SICI code
0163-3864(1997)60:4<382:SCOGFS>2.0.ZU;2-Y
Abstract
Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkget in (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition oc curring at 1.8 mu g/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7'',4'''-tetramethyl ether, kaya flavone, podocarpusflavone A, and amentoflavone.