Sxd. Zhang et al., IMMUNOLOCALIZATION OF APOLIPOPROTEIN-D, ANDROGEN RECEPTOR AND PROSTATE-SPECIFIC ANTIGEN IN EARLY-STAGE PROSTATE CANCERS, The Journal of urology, 159(2), 1998, pp. 548-554
Purpose: To determine the cellular distribution and levels of immunohi
stochemical staining for apolipoprotein D (Apo-D), prostate specific a
ntigen (PSA) and androgen receptor (AR) in early stage prostate cancer
s. Materials and Methods: Cellular distribution of Apo-D, PSA and AR i
n 30 stage A/B prostate cancers and in non-malignant glandular tissue
contained in the same sections was detected immunohistochemically, and
staining was evaluated by computerized video image analysis. Results:
Staining for Apo-D (percentage positive cellular area) was significan
tly increased in tumor cells of early stage prostate cancers compared
with non-malignant glandular tissue. PSA and AR were present at high l
evels in both early stage prostate tumors and non-malignant prostate.
Conclusions: Malignant transformation in the prostate is associated wi
th increased cellular levels of Apo-D.