SYNTHESIS OF DIDOCOSAHEXAENOYLPHOSPHATIDYLSERINE

1,2-Di-O-isopropylideneglycerophosphorochloridate prepared from isopro pylindene glycerol and phosphorus oxychloride, was allowed to react wi th Z-L-serine-N-phthalimidomethyl ester to obtain a derivative of phos phatidylserine. Then, after the isopropylidene group was removed by Am berlite IR-120 (H+), and the phosphate group was also blocked as a Ba- salt, this derivative was coupled with docosahexaenoic acid, applying the method of activated ester. Removal of both protective groups of se rine was finally done by dry hydrogen chloride in chloroform.