GENETIC INFLUENCES ON INSULINEMIA IN NORMOTENSIVE TWINS

Citation
K. Narkiewicz et al., GENETIC INFLUENCES ON INSULINEMIA IN NORMOTENSIVE TWINS, American journal of hypertension, 10(4), 1997, pp. 467-470
Citations number
28
Categorie Soggetti
Peripheal Vascular Diseas
ISSN journal
08957061
Volume
10
Issue
4
Year of publication
1997
Part
1
Pages
467 - 470
Database
ISI
SICI code
0895-7061(1997)10:4<467:GIOIIN>2.0.ZU;2-I
Abstract
The aim of this study was to establish the contribution of genetic fac tors to the variance of plasma insulin concentration in healthy, normo tensive twins. Seventeen pairs of monozygotic (MZ) and 17 pairs of diz ygotic (DZ) twins were investigated. The test of genetic variance reve aled a significantly larger within-pair variance of fasting plasma ins ulin (FPI) and a relative insulin resistance (RIR) in the DZ twins, in comparison with the MZ twins. Both FPI and RIR had a higher intraclas s correlation coefficient in the MZ twins than in the DZ twins; the co rresponding heritability estimates were 0.54 for FPI and 0.66 for RIR. Adjusting for age, gender, and body mass index did not affect heritab ility estimates for either FPI or RIR. Our data indicate that genetic factors are important determinants of insulinemia in normal subjects, independent of body mass index. (C) 1997 American Journal of Hypertens ion, Ltd.