Bs. Chong et al., TISSUE-RESPONSE TO POTENTIAL ROOT-END FILLING MATERIALS IN INFECTED ROOT CANALS, International endodontic journal, 30(2), 1997, pp. 102-114
The tissue responses to two potential root-end filling materials, a li
ght-cured glass ionomer cement (Vitrebond) and a reinforced zinc oxide
-eugenol cement (Kalzinol) were compared with that to amalgam. In 27 p
remolar teeth of beagle dogs (54 roots), a collection of endodontic pa
thogenic bacteria was first inoculated into the root canals to induce
periapical lesions. On each root, an apicectomy was performed and root
-end cavities prepared to receive fillings of each material. The teeth
and surrounding law were removed after 8 weeks (24 roots) and 4 weeks
(30 roots); and they were prepared for histological examination, The
tissue response to amalgam fillings after 4 and 8 weeks was marked by
moderate or severe inflammation on all roots, and extended > 0.5 mm in
10 out of 18 roots. In contrast, after 8 weeks, the majority of roots
filled with Kalzinol showed little or moderate inflammation while the
tissue response to Vitrebond was the best of the three materials, and
was also less extensive. After 4 weeks, the overall best tissue respo
nse was with Kalzinol, followed closely by Vitrebond, The differences
between materials for both time periods with either none or few inflam
matory cells when compared with that with either moderate or severe in
flammation were statistically significant (P<0.01), Similarly, the dif
ferences between materials for both time periods with no inflammation
or inflammation extending <0.2 mm when compared with that with inflamm
ation extending >0.2 mm (less than or equal to 0.5 mm or >0.5 mm) were
statistically significant (P<0.01), Both Vitrebond and Kalzinol have
potential as root-end filling materials as the tissue response was con
siderably more favourable than that to amalgam.