To study factors that cause or prevent injuries, it can be efficient t
o use a case-control study design and select both cases and controls f
rom patients seen in the ED. Bias in case ascertainment can be reduced
by studying exposures that, aside from their influence On the risk of
injury, are unrelated to the use of emergency care. The ideal control
group often includes persons generally not seen in an ED: for example
, those who experience the injury-producing event, such as a bicycle c
rash, but who do not sustain serious injury. However, the exposure exp
erience of the underlying population at risk sometimes can be closely
approximated with information from selected persons seeking emergency
care. With careful attention to the selection of study subjects, valid
case-control studies of the causes of some injuries can be conducted
in the ED.