EXPERIMENTAL-STUDY OF A MIXED VACCINE AGAINST PESTE DES PETITS RUMINANTS AND CAPRIPOX INFECTION IN GOATS IN NORTHERN CAMEROON

A mixed vaccine against peste des petits ruminants (PPR) and capripox infection was investigated in northern Cameroon. The vaccine strains w ere the attenuated PPRV 75/1 strain for PPR and the RM 65 strain for C apripox disease. 25 goats were vaccinated with different doses of the vaccine to study the seroconversion. In another experiment, 20 goats w ere vaccinated and then challenged with wild virulent strains of PPR a nd goat pox. The measure of the seroconversion as well as the challeng e experiments demonstrated that PPR valence was effective at least til l the 10(0.8) tissue culture infective dose 50. However, the capripox valence appeared not to be protective despite the apparition of neutra lising antibodies. The economical benefits of using a low dose of vacc ine against PPR are discussed. Further studies with new vaccinal strai ns of capripox viruses are recommended before investigating clinical f ield trials. (C) 1997 Elsevier Science B.V.