SYNTHESIS OF 5-N-ACETYLARDEEMIN SECO-ANALOGS

Authors
SANCHEZ JD RAMOS MT AVENDANO C
Citation
Jd. Sanchez et al., SYNTHESIS OF 5-N-ACETYLARDEEMIN SECO-ANALOGS, Tetrahedron, 54(5-6), 1998, pp. 969-980
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
5-6
Year of publication
1998
Pages
969 - 980
Database
ISI
SICI code
0040-4020(1998)54:5-6<969:SO5S>2.0.ZU;2-Q
Abstract
Piperazinediones derived from ethyl N-indolylmethyl-glicinate or L-ala ninate and different alpha-amino esters were cyclized with anthranilic acid in two steps with retention of configuration of the stereocenter s to afford compounds which are analogues of 5-N-acetylardeemin, a MDR reversal agent. (C) 1997 Elsevier Science Ltd. All rights reserved.