SURGERY IN THE MANAGEMENT OF SMALL-CELL LUNG-CANCER

Objective: We analyzed our experience in the period January 1975-Decem ber 1995 aiming to confirm the role of surgery in the multimodality tr eatment of small cell lung cancer (SCLC). Methods: 127 patients (5.28% of the overall lung resections for carcinoma) underwent surgery for S CLC. The median age was 60 years (range 34-73). In 87 patients (68.5%) a pre-operative tissue diagnosis was effected and those patients unde rwent a complete staging procedure. Fifteen patients received up to si x complete courses of neoadjuvant and adjuvant chemotherapy. The surgi cal procedures included: 50 pneumonectomies, 71 lobectomies and six we dge resections. Two patients experienced a local recurrence and a comp letion pneumonectomy was performed. Results: The median follow-up is 6 6 months (range 6-214). The 5-year actuarial survival rate is 22.6% (m edian 18 months). Twenty-three patients are still alive, 21 of them be ing disease-free. Considering the most conspicuous group of patients ( n = 92) treated by surgery and adjuvant chemotherapy, the survival dat a were 47.2, 14.8 and 14.4% for Stage I, II and III, respectively (P = 0.001). N0 patients had a significantly better survival than N1 and N 2 patients (P = 0.035). Conclusions: Surgery and adjuvant chemotherapy might represent an effective form of treatment of limited SCLC withou t lymph-node involvement. The role of surgery is yet to be verified as regards N1 and N2 status, where even neoadjuvant chemotherapy has not achieved the hoped-for results (no patient reaching a 2-year survival ). (C) 1997 Elsevier Science B.V.