Objective: To document the existence of residual splenic function afte
r laparoscopic splenectomy in a series of 48 patients. Design: A nonco
mparative descriptive case series. Setting: A tertiary care center. Pa
tients: A series of 9 patients without clinical improvement after lapa
roscopic splenectomy of 48 consecutive patients undergoing laparoscopi
c splenectomy for several hematologic disorders after a mean follow-up
of 16 months (range, 1-40 months). Interventions: A computed tomograp
hic scan and technetium Tc 99m sodium pertechnetate heat-damaged red b
lood cell scintigraphy were performed for patients with partial (plate
let count <100X10(9)/L) or total (platelet count <50X10(9)/L) failure
of improvement. Main Outcome Measure: Evidence of residual splenic tis
sue by image diagnosis. Results: The condition of 9 of the 48 patients
failed to improve after laparoscopic splenectomy. Six patients experi
enced a total failure of improvement and 3 experienced a partial failu
re of improvement (1 patient had human immunodeficiency virus-related
thrombocytopenia and 8 had idiopathic thrombocytopenic purpura). Three
patients had residual splenic function, which was revealed by scintig
raphy. The results of a computed tomographic scan showed an accessory
spleen in one patient and splenic implants in splenic fossa in another
patient. Conclusion: Laparoscopic splenectomy has a promising role in
the management of hematologic diseases requiring splenectomy, but it
requires exquisite care to avoid parenchymal rupture and cell spillage
and to avoid leaving accessory spleens, which can lead to the failure
of surgical treatment.