PREVALENCE OF 6 TYPES OF HUMAN-PAPILLOMAVIRUS IN INVERTED PAPILLOMA AND PAPILLARY TRANSITIONAL-CELL CARCINOMA OF THE BLADDER - AN EVALUATION BY POLYMERASE CHAIN-REACTION

Aims - To study the prevalence of high risk oncogenic human papillomav iruses (HPV) in inverted papilloma and papillary transitional cell car cinoma of the bladder. Methods - Ten cases of inverted papilloma and 2 0 cases of papillary transitional cell carcinoma of the bladder from C hinese patients in Hong Kong were examined for the presence of HPV typ e Si, 11, 16, 18, 31, and 33 genomes using the polymerase chain reacti on and HPV type specific primer probe combinations on paraffin wax emb edded biopsy specimens. Results - Of the 10 cases of inverted papillom a, cases 1 and 6 showed the presence of HPV types 16 and 18, respectiv ely, Six of the 20 papillary transitional cell carcinomas were positiv e for HPV type 18. The other HPV types were not detected. Conclusions - HPV type 18 was found in 60% and 30% of cases of inverted papilloma and papillary transitional cell carcinoma of the bladder, respectively . These tumours were rarely associated with HPV types 6, 11, 16, 31, a nd 33. The role of HPV type 18 in oncogenesis of inverted papilloma an d transitional cell carcinoma of the bladder requires further studies.