SEQUENTIAL ALTERATIONS IN TISSUE LIPOPROTEIN-LIPASE, TRIGLYCERIDE SECRETION RATES, AND SERUM TUMOR-NECROSIS-FACTOR-ALPHA DURING ESCHERICHIA-COLI BACTEREMIC SEPSIS IN RELATION TO THE DEVELOPMENT OF HYPERTRIGLYCERIDEMIA
S. Lanzajacoby et al., SEQUENTIAL ALTERATIONS IN TISSUE LIPOPROTEIN-LIPASE, TRIGLYCERIDE SECRETION RATES, AND SERUM TUMOR-NECROSIS-FACTOR-ALPHA DURING ESCHERICHIA-COLI BACTEREMIC SEPSIS IN RELATION TO THE DEVELOPMENT OF HYPERTRIGLYCERIDEMIA, Shock, 9(1), 1998, pp. 46-51
Citations number
43
Categorie Soggetti
Peripheal Vascular Diseas","Emergency Medicine & Critical Care",Hematology
The time sequence and the mechanisms leading to the development of the
hypertriglyceridemia of bacteremic sepsis are not fully understood, T
his study was conducted to determine the mechanisms leading to the ear
ly rise in serum triglycerides (TG). Bacteremic sepsis was induced in
fasted and parenterally fed rats by intravenous infusion of live Esche
richia coli colonies over a 1 h period every 24 h up to 98 h. Body tem
perature was elevated from 12 to 48 h after E. coli infusion in fasted
rats and from 24 to 72 h after E. coli infusion in fed rats, The init
ial rise in serum TG was observed at 3 h after E. coli infusion; in fa
sted rats this elevation was maintained over 72 h, In the parenterally
fed rats, hypertriglyceridemia was evident only at the 3 h time point
, Serum concentrations of tumor necrosis factor alpha (TNF-alpha) were
elevated significantly at 60 min after initiating the E. coli infusio
n, peaked at 90 min, and declined by 120 min. Immunization with neutra
lizing goat anti-TNF-alpha IgG did not block the initial increase in s
erum TG induced by E. coli. This early rise in TG in fasted E. coli-tr
eated rats was accompanied by a 33% increase in TG secretion in compar
ison with control rats. TG secretion declined by 27% at 9 h and remain
ed depressed at 12 and 24 h in comparison with time-matched control ra
ts. By 24 h lipid accumulation was evident in the livers of the fasted
and fed E. coli-treated rats. Most of the fasted E. coli-treated rats
died by 72 h. Parenteral feeding extended survival of E. coli-treated
rats until 120 h. These findings along with the observation that two
mechanisms are involved in maintaining the elevation of serum TG durin
g E. coli sepsis suggests that the hypertriglyceridemia may be importa
nt in host survival.