ANALYSIS OF DERIVATIZED PROSTAGLANDINS BY CAPILLARY SUPERCRITICAL-FLUID CHROMATOGRAPHY WITH A PHOSPHORUS-SELECTIVE DETECTOR

Authors
DAVID PA NOVOTNY MV
Citation
Pa. David et Mv. Novotny, ANALYSIS OF DERIVATIZED PROSTAGLANDINS BY CAPILLARY SUPERCRITICAL-FLUID CHROMATOGRAPHY WITH A PHOSPHORUS-SELECTIVE DETECTOR, The Journal of microcolumn separations, 10(1), 1998, pp. 27-32
Citations number
19
Categorie Soggetti
Chemistry Analytical
Journal title
The Journal of microcolumn separations → ACNP
ISSN journal
10407685
Volume
10
Issue
1
Year of publication
1998
Pages
27 - 32
Database
ISI
SICI code
1040-7685(1998)10:1<27:AODPBC>2.0.ZU;2-F
Abstract
Model prostaglandins were reacted with dimethylthiophosphinic chloride to form suitable derivatives using dimethylaminopyridine as a catalys t for supercritical fluid chromatography with thermionic detection. Th e high sensitivity of this phosphorus-selective detector-makes it feas ible to detect biologically important prostaglandins and related metab olites in physiological fluids at nanogram-per-milliliter concentratio ns. (C) 1998 John Wiley & Sons, Inc.