Transcription regulation of erythroid-specific genes as well as erythr
oid-specific transcription factors and their role in erythropoiesis ar
e described on the basis of published data and the information accumul
ated in the erythroid-specific gene database (ESG-TRRD). The structura
l organization of locus-controlling regions of alpha- and beta-globin
genes is presented. The mechanisms of tissue- and stage-specific regul
ation of globin gene transcription are discussed.