The indistinguishability of identical quantum particles can lead to qu
antum interferences that profoundly affect their scattering(1,2). If t
wo particles collide and scatter, the process that results in the dete
ction of the first particle in one direction and the second particle i
n another direction interferes quantum mechanically with the physicall
y indistinguishable process where the roles of the particles are rever
sed. For bosons such as photons, a constructive interference between p
robability amplitudes can enhance the probability, relative to classic
al expectations, that both are detected in the same direction-this is
known as 'bunching'. But for fermions such as electrons, a destructive
interference should suppress this probability ('anti-bunching'); this
interference is the origin of the Pauli exclusion principle, which st
ates that two electrons can never occupy the same state. Although two-
particle interferences have been shown for colliding photons(3,4), no
similar demonstration for electrons exists(2,5,6). Here we report the
realization of this destructive quantum interference in the collision
of electrons at a beam splitter. In our experiments, the quantum inter
ference responsible for the Pauli exclusion principle is manifest as t
he suppression in electron current noise after collision.