OCCUPATIONAL EXPOSURE TO SOLVENTS AND HAIRY-CELL LEUKEMIA

Objectives-The role of occupational exposures in hairy cell leukaemia was investigated through a multicentre, hospital based, case-control s tudy. This paper analyses the role of exposure to solvents other than benzene in hairy cell leukaemia. Methods-The study included 226 male c ases and 425 matched controls. exposure to solvents was evaluated by e xpert case by case review of the detailed data on occupational exposur es generated by specific interviews. Also, exposure to solvents was ev aluated with an independantly constructed job exposure matrix (JEM). R esults-No association was found between hairy cell leukaemia and previ ous employment in a job exposed to solvents (odds ratio (OR) 0.9 95% c onfidence interval (95% CI) 0.6 to 1.3). ORs for the main occupational tasks exposed to solvents were around 1 and did not increase with the frequency or the duration of the tasks. No specific type of paint or glue was found to be significantly associated with hairy cell leukaemi a. No association was found with exposure to solvents, taken as a whol e, with either expert assessments or the JEM. No association was found with aromatic, chlorinated, or oxygenated subgroups of solvents. The ORs did not increase with the average intensity of exposure assessed b y the experts, with the frequency of use, or with the duration of expo sure. Finally, no association was found with non-occupational exposure to solvents. Conclusions-The study did mot show any association betwe en exposure to solvents and hairy cell leukaemia.