CALCULATED PROSTATE CARCINOMA VOLUME - THE OPTIMAL PREDICTOR OF 3-YEAR PROSTATE-SPECIFIC ANTIGEN (PSA) FAILURE FREE SURVIVAL AFTER SURGERY OR RADIATION-THERAPY OF PATIENTS WITH PRETREATMENT PSA LEVELS OF 4-20 NANOGRAMS PER MILLILITER
Av. Damico et al., CALCULATED PROSTATE CARCINOMA VOLUME - THE OPTIMAL PREDICTOR OF 3-YEAR PROSTATE-SPECIFIC ANTIGEN (PSA) FAILURE FREE SURVIVAL AFTER SURGERY OR RADIATION-THERAPY OF PATIENTS WITH PRETREATMENT PSA LEVELS OF 4-20 NANOGRAMS PER MILLILITER, Cancer, 82(2), 1998, pp. 334-341
BACKGROUND. In this study, the authors evaluated whether a clinically
relevant stratification of prostate specific antigen (PSA) failure fre
e survival (bNED) after definitive local therapy could be made for pat
ients with prostate carcinoma clinically classified as T1 or T2 and pr
etreatment PSA levels of 4-20 ng/mL. METHODS. Multivariate Cox regress
ion analysis and Kaplan-Meier analysis were performed for clinically l
ocalized prostate carcinoma patients who presented with PSA levels of
4-20 ng/mL. Three hundred forty-eight of the pa tients were managed de
finitively with conventional external beam radiation therapy (median d
ose, 67 gray), whereas 547 of the patients were managed definitively w
ith a radical retropubic prostatectomy. The outcome tested was time to
posttreatment PSA failure. The clinical predictors evaluated included
the standard paradigm (PSA, biopsy Gleason score, and clinical stage)
; type of local therapy; and a newly defined factor, the calculated pr
ostate cancer volume (cV(Ca)). RESULTS. Time to posttreatment PSA fail
ure was equivalent (P = 0.52) independent of the type of local therapy
. The cV(Ca) (P < 0.0001), pretreatment PSA (P = 0.003), and clinical
classification of T2c (P = 0.04) remained significant predictors of ti
me to posttreatment PSA failure in multivariate analysis. CONCLUSIONS.
The staging system described herein, which is based on cV(Ca) and PSA
, may optimize patient selection for definitive local therapy and entr
y onto randomized clinical trials examining the use of adjuvant hormon
al or chemotherapy in patients with clinically localized disease who p
resent with PSA levels of 4-20 ng/mL. Validation of this staging syste
m by other investigators is currently underway. (C) 1998 American Canc
er Society.