The concept of physiological individual response specificity (IRS) was
critically discussed. A review of empirical studies focused on IRS ma
gnitude, stability, and personality correlates. Using difference score
s, an average of 33% of the participants showed a significant IRS. IRS
stability was found in only 15% of the participants. In some studies,
IRS incidence was associated with neuroticism or stress coping styles
. We suggest that the IRS concept should include not only purely const
itutional but also situational and psychological determinants. Predict
ions from this revised biopsychological model were tested with a data
set comprising 48 healthy male participants who completed six tasks, w
hich were replicated three times in 1-week intervals. At Session 1, 21
% of the participants displayed a significant IRS. IRS stability was f
ound in only 8% of the participants. Participants with a significant I
RS at Session 1 reported higher levels of fear (anger and happiness as
covariates) and of pounding heart. Between-session IRS (trait-IRS) bu
t not within-session IRS (state-IRS) was associated with trait anxiety
.