PROTECTION AGAINST POSTISCHEMIC NEURONAL LOSS IN GERBIL HIPPOCAMPAL CA1 BY GLYCINE(B) AND AMPA ANTAGONISTS

Authors
LAZAREWICZ JW GADAMSKI R PARSONS CG DANYSZ W
Citation
Jw. Lazarewicz et al., PROTECTION AGAINST POSTISCHEMIC NEURONAL LOSS IN GERBIL HIPPOCAMPAL CA1 BY GLYCINE(B) AND AMPA ANTAGONISTS, Journal of neural transmission, 104(11-12), 1997, pp. 1249-1254
Citations number
15
Journal title
Journal of neural transmission → ACNP
ISSN journal
03009564
Volume
104
Issue
11-12
Year of publication
1997
Pages
1249 - 1254
Database
ISI
SICI code
0300-9564(1997)104:11-12<1249:PAPNLI>2.0.ZU;2-0
Abstract
Novel antagonists of the glycine, site of the NMDA receptor (MRZ 2/570 , MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-m in. global ischaemia in gerbils. Untreated animals showed after 14 day s a loss of almost 90% of pyramidal neurones in the CA1 region, which was prevented by NBQX, and reduced to 50% by both glycine, antagonists . NBQX produced a delayed, long lasting (up to 24 hr) hypothermia whil e hypothermia with both glycine(B) antagonists was transient.