SELECTIVE 5'-O-ACETYLATION OF 2'-DEOXYNUCLEOSIDES AND NUCLEOSIDES BY A MODIFIED MITSUNOBU PROCEDURE

Authors
HE GX BISCHOFBERGER N
Citation
Gx. He et N. Bischofberger, SELECTIVE 5'-O-ACETYLATION OF 2'-DEOXYNUCLEOSIDES AND NUCLEOSIDES BY A MODIFIED MITSUNOBU PROCEDURE, Nucleosides & nucleotides, 16(3), 1997, pp. 257-263
Citations number
8
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
3
Year of publication
1997
Pages
257 - 263
Database
ISI
SICI code
0732-8311(1997)16:3<257:S5O2AN>2.0.ZU;2-H
Abstract
5'-Hydroxyl groups of deoxynucleosides and nucleosides except for guan osine can be acetylated in high yields and selectivities through a mod ified Mitsunobu procedure by adding diethyl azodicarboxylate to a susp ension of the deoxynucleoside or nucleoside in dioxane containing trip henylphosphine and excess acetic acid at 60 degrees C.