AMOYL-3(5)-(2-DEOXY-BETA-D-RIBOFURANOSYL)PYRAZOLES - APPLICATION OF PALLADIUM-CATALYZED GLYCAL COUPLING METHODOLOGY TO THE SYNTHESIS OF PYRAZOFURIN ANALOGS

Authors
ERION MD RYDZEWSKI RM
Citation
Md. Erion et Rm. Rydzewski, AMOYL-3(5)-(2-DEOXY-BETA-D-RIBOFURANOSYL)PYRAZOLES - APPLICATION OF PALLADIUM-CATALYZED GLYCAL COUPLING METHODOLOGY TO THE SYNTHESIS OF PYRAZOFURIN ANALOGS, Nucleosides & nucleotides, 16(3), 1997, pp. 315-337
Citations number
27
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
3
Year of publication
1997
Pages
315 - 337
Database
ISI
SICI code
0732-8311(1997)16:3<315:A-AOP>2.0.ZU;2-O
Abstract
Analogs of the C-nucleoside pyrazofurin were prepared in 7-9 steps usi ng a key Pd(0)-catalyzed coupling reaction between protected iodopyraz oles 6a and 6b and glycal 8 to form the glycosyl bond. Conditions for this reaction were improved from those previously described for relate d reactions in order to maximize product yields and eliminate the need for triphenylarsine.