INHIBITION OF TUMOR PROMOTER-INDUCED EPSTEIN-BARR-VIRUS ACTIVATION BYDIOSPYRIN, A PLANT-DERIVED ANTITUMOR COMPOUND, AND ITS SYNTHETIC DERIVATIVES

Authors
NORHANOM AW HAZRA B
Citation
Aw. Norhanom et B. Hazra, INHIBITION OF TUMOR PROMOTER-INDUCED EPSTEIN-BARR-VIRUS ACTIVATION BYDIOSPYRIN, A PLANT-DERIVED ANTITUMOR COMPOUND, AND ITS SYNTHETIC DERIVATIVES, PTR. Phytotherapy research, 11(8), 1997, pp. 588-590
Citations number
20
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
11
Issue
8
Year of publication
1997
Pages
588 - 590
Database
ISI
SICI code
0951-418X(1997)11:8<588:IOTPEA>2.0.ZU;2-M
Abstract
Inhibition of tumour promotion by diospyrin, a plant-derived bioactive bisnaphthoquinonoid compound, and its two derivatives was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV ) early antigen (EA) expression in EBV- genome-carrying human lymphobl astoid cells, Synthetic modifications of diospyrin resulted in positiv e improvement of its activity against tumour promotion by inhibiting E BV EA expression in Raji cells induced by 12-o-tetradecanoylphorbol-13 -acetate (TPA). (C) 1997 John Wiley & Sons, Ltd.