AN ELUENT-JET INTERFACE FOR CHEMICAL-IONIZATION MASS-SPECTROMETRY ANDCOUPLING OF MICROCOLUMN LIQUID-CHROMATOGRAPHY WITH ELECTRON IONIZATION MASS-SPECTROMETRY

An improved eluent-jet interface was used to combine flow-injection an alysis (FIA) and micro-column Liquid chromatography (LC) on-line with mass spectrometry (MS) in the electron ionization (EI) and solvent-ind ependent chemical ionization (CI) modes. Good results were obtained fo r a series of pesticides and for 2-(diethylamino)ethanol (DEAE), a pre cursor of the chemical warfare V-agents. When using single-ion monitor ing, 50 pg of DEAE could be detected in the CI mode, and a linear cali bration plot was obtained in the test range of 50-1000 pg. EI-MS spect ra obtained in both FIA and micro-LC experiments were closely analogou s to those in conventional mass spectral libraries. (C) 1998 John Whey & Sons, Ltd.