CLINICOPATHOLOGICAL FEATURES OF RESECTED PRIMARY ADENOSQUAMOUS CARCINOMAS OF THE LIVER

Four cases of resected adenosquamous carcinoma of the liver were clini copathologically reviewed, together with immunohistochemical findings. Although no lymph node metastases were seen and a curative resection was achieved in all cases, two patients had recurrences in the periton eum and distant organs such as the pericardium and pleura relatively s oon after the operation. Of the remaining two cases, one patient died during the postoperative period and the other died of coexistent hilar cholangiocarcinoma. Together these findings suggest that this disease tends to spread locally and distantly in the early phase of tumor gro wth and shows aggressive biological behavior. In an immunohistochemica l study, involucrin was a specific marker for the squamous component a nd CA19-9 was a marker for the adenomatous component.