Abdominal bloating, weight loss, pneumoperitoneum, and ascites develop
ed in a 73-year-old woman, She had scleroderma, megajejunum, small bow
el dysmotility and bacterial overgrowth. After treatment with a course
of antibiotics, the pneumoperitoneum and ascites resolved, but her sy
mptoms and the pneumoperitoneum recurred after the antibiotics were st
opped. She was placed on cyclical antibiotics, and during a 2-year fol
low-up period she has remained well. The pneumoperitoneum and ascites
may have been secondary to small bowel bacterial overgrowth. Ours is t
he first case that demonstrates this association.