LOW-DOSE ONDANSETRON WITH DEXAMETHASONE MORE EFFECTIVELY DECREASES VOMITING AFTER STRABISMUS SURGERY IN CHILDREN THAN DOES HIGH-DOSE ONDANSETRON

Background: Ondansetron and dexamethasone have been observed to decrea se the incidence of vomiting by children after general anesthesia. Thi s study compared the effect of high-dose (150 mu g/kg) ondansetron wit h low-dose (50 mu g/kg) ondansetron plus 150 mu g/kg dexamethasone on the incidence of vomiting after strabismus in children. Methods: This study had a double-blind, blocked, stratified, randomized design. With parental consent and Hospital Ethics Committee approval, healthy chil dren aged 2-14 yr who were undergoing elective strabismus surgery were studied. Anesthesia was induced intravenously with propofol or by inh alation with halothane and nitrous oxide. Patients in the high-dose gr oup were given placebo plus 150 mu g/kg (maximum dose, 8 mg) of ondans etron intravenously, whereas patients in the low-dose group were given 150 mu g/kg dexamethasone (maximum dose, 8 mg) and 50 mu g/kg ondanse tron intravenously In a double-blind manner, Anesthesia was maintained with halothane and nitrous oxide. All incidences of vomiting occurrin g as long as 24 h after anesthesia were recorded. Results: Three of th e 200 patients enrolled in the study were excluded from data analysis. The groups were similar with respect to demographic data and potentia l confounding variables. Patients vomited from 0-12 times. The low-dos e ondansetron plus dexamethasone group had a lower incidence of vomiti ng, 9% (95% CI = 4-17%) versus 28% (95% CI = 20-38%; p < 0.001). Only 1% of the patients in the low-dose ondansetron plus dexamethasone grou p vomited while in the hospital. Conclusions: Low-dose ondansetron plu s dexamethasone is an effective prophylactic antiemetic combination fo r children undergoing strabismus surgery.