RISK-FACTORS ASSOCIATED WITH LOCAL RECURRENCE AFTER CURATIVE RESECTION FOR RECTAL-CANCER

A retrospective study was conducted to identify the factors related to locoregional recurrence in patients who underwent curative resections for primary rectal cancer between January 1986 and April 1994 at Anka ra Oncology Hospital in Turkey. A step-wise logistic regression analys is was applied for 116 patients two had complete follow-up. Age, sex, macroscopic size of the lesion, tumor location in the rectum as determ ined by the distance from the anal verge, obstruction at presentation, tumor histology, lymphatic invasion, venous invasion, stage according to TNM classification, differentiation of the tumor, surgical treatme nt modality, radical abdominopelvic lymphadenectomy (RAPL), and blood transfusion were used as the clinico-pathologic variables. Locoregiona l recurrent disease was found after a mean follow-up period of 52 mont hs in 28 (24.1%) patients, while the median recurrence-free period was 12 months. Univariate analysis demonstrated that age, disease stage, tumor grade, obstruction, RAPL, blood transfusion, and venous and lymp hatic invasion were significant risk factors (P < 0.05); however, usin g multivariate analysis, an increased risk for the development of loco regional recurrence was found to be associated with: age (P = 0.0052), stage (P = 0.0379), blood transfusion (P = 0.0276), obstruction (P = 0.0035), and RAPL fusion (P (P = 0.0069).