A. Eroglu et al., RISK-FACTORS ASSOCIATED WITH LOCAL RECURRENCE AFTER CURATIVE RESECTION FOR RECTAL-CANCER, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 27(12), 1997, pp. 1113-1118
A retrospective study was conducted to identify the factors related to
locoregional recurrence in patients who underwent curative resections
for primary rectal cancer between January 1986 and April 1994 at Anka
ra Oncology Hospital in Turkey. A step-wise logistic regression analys
is was applied for 116 patients two had complete follow-up. Age, sex,
macroscopic size of the lesion, tumor location in the rectum as determ
ined by the distance from the anal verge, obstruction at presentation,
tumor histology, lymphatic invasion, venous invasion, stage according
to TNM classification, differentiation of the tumor, surgical treatme
nt modality, radical abdominopelvic lymphadenectomy (RAPL), and blood
transfusion were used as the clinico-pathologic variables. Locoregiona
l recurrent disease was found after a mean follow-up period of 52 mont
hs in 28 (24.1%) patients, while the median recurrence-free period was
12 months. Univariate analysis demonstrated that age, disease stage,
tumor grade, obstruction, RAPL, blood transfusion, and venous and lymp
hatic invasion were significant risk factors (P < 0.05); however, usin
g multivariate analysis, an increased risk for the development of loco
regional recurrence was found to be associated with: age (P = 0.0052),
stage (P = 0.0379), blood transfusion (P = 0.0276), obstruction (P =
0.0035), and RAPL fusion (P (P = 0.0069).