Rapidly growing mycobacteria have occasionally been reported to cause
catheter-related infections. We report a case of a central venous cath
eter-related bacteremia, caused by Mycobacterium smegmatis, in a patie
nt with cancer. Cultures of the catheter tip and blood cultures grew M
smegmatis and Enterococcus faecalis. The patient responded to cathete
r removal and a 3-month course of antibiotics (doxycycline and ciprofl
oxacin), Based on our experience and the reported experience with othe
r rapidly growing mycobacteria, M smegmatis catheter-related bacteremi
a should be treated with catheter removal and a course of appropriate
antibiotics, based on in vitro susceptibility testing.